Method of treating psoriasis, arthritis and reducing the toxicity of cancer chemotherapy
Abstract The present invention is a method of treating a person who has psoriasis or arthritis or reducing the toxicity of cancer chemotherapy which comprises administering to the patient an anti-psoriasis effective amount of an oxazolidinone, preferably (S)-N-[[3-[3-fluoro-4-(4-morpholinyl)phenyl]-2-oxo-5-oxazolidinyl]methyl]a cetamide. ——————————————————————————– Inventors: Batts; Donald Herman (Kalamazoo, MI), Ulrich; Roger G. (Gurnee, IL) Assignee: Pharmacia & Upjohn [...]
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Retinoyloxy (alkyl-substituted) methyl butyrates useful for the treatment of cancer and other proliferative diseases
Abstract This invention relates to the novel compounds of Formula (I) and pharmaceutical compositions containing same, to methods of treating, preventing or ameliorating cancer and other proliferative diseases in a subject in need of such treatment comprising administering a compound of Formula (I) and pharmaceutically-acceptable salts and prodrugs thereof. ##STR1## The compounds of the invention [...]
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Biotherapy of cancer by targeting TP-3/P80
Abstract Cytotoxic biotherapeutic agents effective for treating certain types of cancer in humans are provided which comprise the TP-3 murine monoclonal antibody chemically conjugated to pokeweed antiviral protein (PAP). The invention further provides a method which utilizes the disclosed cytotoxic biotherapeutic agents to systemically treat cancer patients. With slight modifications the method of the present [...]
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Isolated nucleic acid molecules associated with colon cancer and methods for diagnosing and treating colon cancer
Abstract Various molecules associated with disorders such as colon cancer are disclosed. The invention also discloses diagnostic and therapeutic methods based upon these molecules. ——————————————————————————– Inventors: Scanlan; Matthew J. (New York, NY), Chen; Yao-Tseng (New York, NY), Stockert; Elisabeth (New York, NY), Old; Lloyd J. (New York, NY) Assignee: Ludwig Institute for Cancer Research (New [...]
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Use of 4′-bromoflavone in a cancer chemopreventative composition and method
Abstract A composition and method of cancer chemoprevention is disclosed. The composition and method utilize 4′-bromoflavone as a cancer chemo-preventative agent in mammals, including humans. ——————————————————————————– Inventors: Kosmeder, II; Jerome W. (Oak Park, IL), Moriarty; Robert M. (Chicago, IL), Pezzuto; John M. (River Forest, IL), Song; Lynda Li (Arlington Heights, IL), Moon; Richard C. (Plant [...]
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Materials and methods relating to the identification and sequencing of the BRCA2 cancer susceptibility gene and uses thereof
Abstract The identification and sequencing of the BRCA2 gene is disclosed as well as the amino acid sequence of the corresponding BRCA2 polypeptides. BRCA2 alleles including those with mutations in the BRCA2 gene which are associated with a predisposition to develop cancer, especially breast and ovarian cancer are also disclosed. The present invention further relates [...]
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