Indolocarbazole derivatives useful for the treatment of neurodegenerative diseases and cancer

Abstract Novel indolocarbazole derivatives potentially useful for the treatment of dementias characterized by tau hyperphosphorylation [Alzheimer’s disease (AD), frontal lobe degeneration (FLD), argyrophilic grains disease, subacute sclerotizing panencephalitis (SSPE) as a late complication of viral infections in the CNS], and cancer. ——————————————————————————– Inventors: Roder; Hanno (Ratingen, DE), Lowinger; Timothy B. (Nishinomiya, JP), Brittelli; David R. […]

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Prediction of prostate cancer progression by analysis of selected predictive parameters

Abstract A method for screening individuals at risk for prostate cancer progression is disclosed. The method is useful for evaluating cells from patients at risk for recurrence of prostate cancer following surgery for prostate cancer. Specifically, the method uses specific Markovian nuclear texture factors, alone or in combination with other biomarkers, to determine whether the […]

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Brassieres for reducing breast cancer

Abstract A brassier for reducing breast cancer includes cups for holding the mammary glands. Each of the cups has a slot formed therein for accommodating a papilla. Each slot is longitudinally elongated to accommodate for variances in the longitudinal location of the papilla from woman to woman. By positioning the papilla within the slots, the […]

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Methods for the detection of cervical cancer

Abstract The invention provides a wide range of methods and compositions for detecting and treating cervical cancer in an individual. Specifically, the invention provides target cervical cancer-associated proteins, which permit a rapid detection, preferably before metastases occur, of cervical cancer. The target cervical cancer-associated protein, may be detected, for example, by reacting the sample with […]

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Prevention of ovarian cancer by administration of progestin products

Abstract The present invention relates to methods for preventing the development of epithelial ovarian cancer by administering progestin products, either alone or in combination with other agents such as estrogen products. ——————————————————————————– Inventors: Rodriguez; Gustavo C. (Durham, NC), Hughes, Jr.; Claude L. (Mebane, NC) Assignee: New Life Pharmaceuticals Inc. (Chicago, IL) Appl. No.: 08/713,834 Filed: […]

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Carboxylic acid derivatives, their preparation and use in treating cancer

Abstract This invention provides a method for treating cancer in an individual, wherein the cancer is a tumor in which endothelin is upregulated (e.g. tumors of the prostate, lung, liver, breast, brain, stomach, colon, endometrium, testicle, thyroid, pituatary, bladder, kidney, pancreas and meninges) by administering to the individual an effective amount of a compound of […]

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